Clinical Effectives

Chronic venous insufficiency
Antioxidants
Capillary fragility
Retinopathy
Pancreatic insufficiency

Active Constituents

Grape seed contains Proanthocyanidins, of which also called "OPCs" for oligomeric procyanidins or "PCOs" for procyanidolic oligomers-are a class of nutrients belonging to the flavonoid family.
Proanthocyanidins have antioxidant activity and they play a role in the stabilization of collagen and maintenance of elastin-two critical proteins in connective tissue that support organs, joints, blood vessels, and muscle. Possibly because of their effects on blood vessels, proanthocyanidins have been reported in double-blind research to reduce the duration of edema after face-lift surgery from 15.8 to 11.4 days. In preliminary research, proanthocyanidins were reported to have anti-mutagenic activity (i.e., to prevent chromosomal mutations).